Recent findings on the role of wild-type and mutant p53 in cancer ...
R175H and R273H are more prone to aggregation than wild-type (WT) p53, and their pathological aggregation can lead to various cancers. A recent study investigated the dynamic and …
Upregulation of wild-type p53 by small molecule-induced
May 25, 2021 · Here, we reported that a new quinolone compound RYL-687 significantly inhibited non-small cell lung cancer (NSCLC) cells which express wild type (wt) p53, in contract to its …
Wt p53 impairs response to chemotherapy: make lemonade to …
Jul 13, 2012 · As published recently in Cancer Cell, p53 impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. I discuss that, while treating tumors …
Understanding the complexity of p53 in a new era of tumor …
May 9, 2024 · Here, we review the complexity of different layers of p53 regulation, and the recent advance of the p53 pathway in metabolism, ferroptosis, immunity, and others that contribute to …
The p53 Pathway in Glioblastoma - PMC
The high prevalence and expression of p53 mutations in GBM makes them an important target for precision medicine therapies. Reactivating or restoring wt-p53 would be a promising therapy …
p53: A tale of complexity and context - Cell Press
Mar 28, 2024 · Bottom: wild-type (WT) p53 helps maintain metabolic homeostasis and genome integrity and restrains cancer-associated processes, thereby suppressing tumorigenesis.
Wild-type p53 oligomerizes more efficiently than p53 hot-spot …
Aug 8, 2018 · Single residue changes, caused by hot-spot mutations of the TP53 gene in human cancer, transform wild-type (wt) p53 tumor suppressor proteins into potent oncoproteins - with …
The deubiquitinase inhibitor WP1130 drives nuclear aggregation …
6 days ago · Mutp53 inhibits the transactivation function of WT p53 by exerting a dominant-negative effect. Therefore, we hypothesize that WP1130 treatment may cause ubiquitinated …
p53 activates circASCC3 to repress R-loops and enhance ... - PNAS
In contrast, knockdown of p53 using two independent siRNAs significantly reduced the expression of circASCC3 and ASCC3 in cancer cells when treated with Cisplatin or Nutlin-3 (Fig. 2 E–G …
Suppression of stress granule formation is a vulnerability imposed …
Mar 10, 2025 · To test this hypothesis, we knocked down mutp53 in Huh7 (p53 Y220C), SNU449 (p53 A161T), and HepG2 (p53 wt) HCC cells (Fig. 1b and Supplementary Fig. S1b–d), or …