
BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells
Jan 1, 1999 · BLNK (B cell LiNKer protein), a substrate for Syk, is now shown to be essential in activating phospholipase C (PLC)γ2 and JNK. The BCR-induced PLCγ2 activation, but not the …
B-cell linker - Wikipedia
BLNK’s function and interaction shown in a schematic of BCR signaling pathways. BCR antigen recognition activates Src family kinases, including the SYK and BTK tyrosine kinases. Syk …
BLNK mediates Syk-dependent Btk activation - PMC - National …
Feb 2, 2001 · The SH2 domain-dependent interaction of Btk with BLNK may induce a conformational change in Btk that enables it to serve as the Syk substrate, or alternatively may …
The Direct Recruitment of BLNK to Immunoglobulin α Couples …
Following B-cell antigen receptor (BCR) ligation, the cytoplasmic domains of immunoglobulin α (Igα) and Igβ recruit Syk to initiate signaling cascades. The coupling of Syk to several distal …
BLNK: Immunity - Cell Press
Jul 1, 1998 · We report here the identification and characterization of a novel PTK substrate, BLNK, which is phosphorylated by Syk. Overexpression of wild-type BLNK results in enhanced …
BLNK: a central linker protein in B cell activation - PubMed
We describe here the identification of a novel B cell linker protein, termed BLNK, that interfaces the B cell receptor-associated Syk tyrosine kinase with PLCgamma, the Vav guanine …
BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in …
BLNK (B cell LiNKer protein), a substrate for Syk, is now shown to be essential in activating phospholipase C (PLC)gamma 2 and JNK. The BCR-induced PLC gamma 2 activation, but …
B and T Lymphocyte Attenuator Regulates B Cell Receptor …
Feb 1, 2009 · Downstream of Syk, B cell linker protein (BLNK) and phospholipase Cγ2 (PLCγ2) also show lower phosphorylation levels upon BTLA signaling, indicating reduced activity of the …
BLNK negatively regulates innate antifungal immunity through
Oct 16, 2024 · Here, we elucidate that C-type lectin receptors (CLRs) govern the Syk-mediated activation of BLNK, leading to the inhibition of macrophage migration by disrupting podosome …
Requirement for B Cell Linker Protein (BLNK) in B Cell …
Dec 3, 1999 · In B cells, B cell linker protein (BLNK) links the B cell receptor (BCR)–activated Syk kinase to the phosphoinositide and mitogen-activated kinase pathways. To examine the in vivo …
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