
BLNK Required for Coupling Syk to PLCγ2 and Rac1-JNK in B Cells
Jan 1, 1999 · BLNK (B cell LiNKer protein), a substrate for Syk, is now shown to be essential in activating phospholipase C (PLC)γ2 and JNK. The BCR-induced PLCγ2 activation, but not the JNK activation, was restored by introduction of PLCγ2 membrane-associated form into BLNK-deficient B cells.
B-cell linker - Wikipedia
BLNK’s function and interaction shown in a schematic of BCR signaling pathways. BCR antigen recognition activates Src family kinases, including the SYK and BTK tyrosine kinases. Syk then phosphorylates BLNK, which can recruit downstream signaling molecules such …
BLNK mediates Syk-dependent Btk activation - PMC - National …
Feb 2, 2001 · The SH2 domain-dependent interaction of Btk with BLNK may induce a conformational change in Btk that enables it to serve as the Syk substrate, or alternatively may prompt the appropriate colocalization of Btk and Syk …
The Direct Recruitment of BLNK to Immunoglobulin α Couples …
Following B-cell antigen receptor (BCR) ligation, the cytoplasmic domains of immunoglobulin α (Igα) and Igβ recruit Syk to initiate signaling cascades. The coupling of Syk to several distal substrates requires linker protein BLNK. However, the ...
BLNK: Immunity - Cell Press
Jul 1, 1998 · We report here the identification and characterization of a novel PTK substrate, BLNK, which is phosphorylated by Syk. Overexpression of wild-type BLNK results in enhanced tyrosine phosphorylation of PLCγ, receptor-mediated calcium responses and transcriptional activation of NF-AT.
BLNK: a central linker protein in B cell activation - PubMed
We describe here the identification of a novel B cell linker protein, termed BLNK, that interfaces the B cell receptor-associated Syk tyrosine kinase with PLCgamma, the Vav guanine nucleotide exchange factor, and the Grb2 and Nck adapter proteins.
BLNK required for coupling Syk to PLC gamma 2 and Rac1-JNK in …
BLNK (B cell LiNKer protein), a substrate for Syk, is now shown to be essential in activating phospholipase C (PLC)gamma 2 and JNK. The BCR-induced PLC gamma 2 activation, but not the JNK activation, was restored by introduction of PLC gamma 2 membrane-associated form into BLNK-deficient B cells.
B and T Lymphocyte Attenuator Regulates B Cell Receptor …
Feb 1, 2009 · Downstream of Syk, B cell linker protein (BLNK) and phospholipase Cγ2 (PLCγ2) also show lower phosphorylation levels upon BTLA signaling, indicating reduced activity of the BCR signal transduction cascade.
BLNK negatively regulates innate antifungal immunity through
Oct 16, 2024 · Here, we elucidate that C-type lectin receptors (CLRs) govern the Syk-mediated activation of BLNK, leading to the inhibition of macrophage migration by disrupting podosome ring formation upon stimulation with fungal β-glucans or α-mannans.
Requirement for B Cell Linker Protein (BLNK) in B Cell …
Dec 3, 1999 · In B cells, B cell linker protein (BLNK) links the B cell receptor (BCR)–activated Syk kinase to the phosphoinositide and mitogen-activated kinase pathways. To examine the in vivo role of BLNK, mice deficient in BLNK were generated.
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