It is well known that smooth muscle is short of transverse striations found in skeletal and cardiac muscle cells, and is often found in the muscular layers of gastrointestinal, respiratory, urogenital, vascular, and lymphatic vessels, as well as in the tunica of some parenchymal organs.

May 29, 2025 · The rupture of atherosclerotic plaque and formation of thrombi leads to myocardial infarction and stroke, which are the major causes of death worldwide. 1 Understanding the mechanisms that control plaque growth, composition, and stability is critical to preventing fatal complications of plaque rupture. Thanks to technical advances, it is increasingly recognized that vascular smooth muscle ...

Sep 24, 2020 · Analogous to the heart, the combination of cells and nuclei allowed us to capture and resolve major cell lineages, including cardiomyocyte, fibroblasts, endothelial cells, smooth muscle cells ...

These receptors are expressed on cardiac myocytes, vascular smooth muscle cells (VSMC) and endothelial cells, and signalling through them orchestrates the normal physiological control of vascular tone, heart rate, and contractility.

These observations provide an insight into the origin of cardiac and smooth muscle cells at the boundary of the atrial chamber and inflow tract, and the mechanism underlying the formation of heart-vessel junctions.

Jul 17, 2023 · Almost every artery in the body supplies blood to smooth muscle whether that is in the form of endothelial smooth muscle located directly in the artery or smooth muscle within an organ system such as arteries of the gastrointestinal tract.

Feb 10, 2025 · The developmental diversity among smooth muscle cells (SMCs) plays a crucial role in segment-specific aortic diseases. However, traditional genetic approaches are inadequate for enabling in vivo analysis of disease susceptibility associated with cellular origin.

Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ. Dev Biol . 1996; 174 :221–232. Crossref

Objective: Smooth muscle cells (SMCs) of the proximal thoracic aorta are embryonically derived from the second heart field (SHF) and cardiac neural crest (CNC). However, distributions of these embryonic origins are not fully defined.

May 24, 2012 · Vascular smooth muscle cells (VSMCs) are the stromal cells of the vascular wall, and, due to their myosin/actin interactions, they are also responsible for arterial contractile tonus and regulating blood pressure and flow in relation to specific metabolic demands.