Sirpα on tumor-associated myeloid cells restrains antitumor
Jan 10, 2024 · Sirpa−/− macrophages presented strong phagocytosis and antigen presentation to enhance T cell activation and proliferation. Furthermore, Sirpa−/− macrophages facilitated T …
Sirpα on tumor-associated myeloid cells restrains antitumor
Sirpa-/-macrophages presented strong phagocytosis and antigen presentation to enhance T cell activation and proliferation. Furthermore, Sirpa -/- macrophages facilitated T cell recruitment …
Supporting this, Syk inhibitor GS-9973 prevents podocyte antigen presentation, resulting in a decrease of T cell activation and mitigation of renal disease caused by SIRPa knockdown or …
CD47 ligation repositions the inhibitory receptor SIRPA to …
We found that CD47 ligation altered SIRPA localization, positioning SIRPA for activation at the phagocytic synapse. At the phagocytic synapse, SIRPA inhibited integrin activation to limit …
(PDF) Sirpα on tumor-associated myeloid cells restrains antitumor ...
Jan 10, 2024 · Sirpa−/− macrophages presented strong phagocytosis and antigen presentation to enhance T cell activation and proliferation. Furthermore, Sirpa−/− macrophages facilitated T …
Podocyte SIRPα reduction aggravates lupus nephritis via …
May 28, 2024 · Here, we report that SIRPα controls podocyte antigen presentation in specific T cell activation via inhibiting spleen tyrosine kinase (Syk) phosphorylation. First, podocyte …
Researchers discover that Sirpα on tumor-associated myeloid cells ...
Jan 16, 2024 · Associate Professor Wenfei Jin from the School of Life Sciences at the Southern University of Science and Technology (SUSTech) led a research group that discovered …
SIRPB1 regulates inflammatory factor expression in the glioma ...
Apr 9, 2024 · SIRPB1 activation with certain antibodies results in SYK phosphorylation and the subsequent activation of calcium, MAPK, and NF-κB signaling pathways. This phenomenon is …
Anticancer efficacy of monotherapy with antibodies to SIRPα ... - PNAS
Dec 23, 2021 · We found that monotherapy with an anti-SIRPα/SIRPβ1 antibody (Ab) suppresses tumor formation by bladder and mammary cancer cells in mice. This effect is likely mediated …
CD47 Ligation Repositions the Inhibitory Receptor SIRPA to …
Aug 18, 2020 · CD47 acts as a “don’t eat me” signal that protects cells from phagocytosis by binding and activating its receptor SIPRA on macrophages. CD47 suppresses multiple …
- Some results have been removed