Jan 10, 2024 · Sirpa−/− macrophages presented strong phagocytosis and antigen presentation to enhance T cell activation and proliferation. Furthermore, Sirpa−/− macrophages facilitated T cell recruitment...

Sirpa-/-macrophages presented strong phagocytosis and antigen presentation to enhance T cell activation and proliferation. Furthermore, Sirpa -/- macrophages facilitated T cell recruitment via Syk/Btk-dependent Ccl8 secretion.

Supporting this, Syk inhibitor GS-9973 prevents podocyte antigen presentation, resulting in a decrease of T cell activation and mitigation of renal disease caused by SIRPa knockdown or deletion. Our findings reveal an immunoregulatory role of SIRPa loss in promoting podocyte antigen presentation to

We found that CD47 ligation altered SIRPA localization, positioning SIRPA for activation at the phagocytic synapse. At the phagocytic synapse, SIRPA inhibited integrin activation to limit macrophage spreading across the surface of the engulfment target.

Jan 10, 2024 · Sirpa−/− macrophages presented strong phagocytosis and antigen presentation to enhance T cell activation and proliferation. Furthermore, Sirpa−/− macrophages facilitated T cell recruitment...

May 28, 2024 · Here, we report that SIRPα controls podocyte antigen presentation in specific T cell activation via inhibiting spleen tyrosine kinase (Syk) phosphorylation. First, podocyte SIRPα under lupus nephritis (LN) conditions is strongly downregulated.

Jan 16, 2024 · Associate Professor Wenfei Jin from the School of Life Sciences at the Southern University of Science and Technology (SUSTech) led a research group that discovered alternative antitumor signaling...

Apr 9, 2024 · SIRPB1 activation with certain antibodies results in SYK phosphorylation and the subsequent activation of calcium, MAPK, and NF-κB signaling pathways. This phenomenon is primarily observed in myeloid-derived cells as opposed to glioma cells.

Dec 23, 2021 · We found that monotherapy with an anti-SIRPα/SIRPβ1 antibody (Ab) suppresses tumor formation by bladder and mammary cancer cells in mice. This effect is likely mediated by promoting the cytotoxic and phagocytic activity of macrophages against tumor cells.

Aug 18, 2020 · CD47 acts as a “don’t eat me” signal that protects cells from phagocytosis by binding and activating its receptor SIPRA on macrophages. CD47 suppresses multiple different pro-engulfment “eat me” signals, including immunoglobulin G (IgG), complement, and calreticulin, on distinct target cells.