Oct 5, 2022 · Serotonin transporters on the platelet membrane and enterochromaffin cells function to uptake serotonin into those cells. Serotonin escapes uptake, and liver metabolism reaches the lung, which then undergoes metabolism.

In this review, we discuss the role of serotonin in regulating metabolism, how tissue disequilibrium of serotonergic signaling can manifest as metabolic disease, and how emerging evidence implicates serotonin as a critical sensor of nutrient balance …

The action of MAO converts serotonin to 5-hydroxyindole acetaldehyde, which in turn is readily metabolized, principally by an isoform of aldehyde dehydrogenase (ALDH2) located in mitochondria, to produce 5-hydroxyindole acetic acid as …

For many years, serotonin has been suspected of playing a pathophysiologic role in PAH. However, serotonin metabolism is complex, with a transporter and several distinct receptors that orchestrate multiple functions in different organ systems.

Aug 1, 2019 · In mammals, serotonin produced within the central nervous system regulates behavior, suppresses appetite, and promotes energy expenditure by increasing sympathetic drive to brown adipose tissue.

Serotonin Metabolic Pathway. The metabolism of serotonin is mainly carried out by enzymes such as monoamine oxidase (MAO) and indoleamine 2,3-dioxygenase (IDO). MAO is responsible for degrading serotonin into 5-hydroxyindoleacetic acid (5-HIAA), while IDO converts tryptophan into kynurenine (Kyn).

Oct 10, 2022 · Our analyses revealed a noncanonical pathway of serotonin biosynthesis via phenylalanine hydroxylase (PAH-1) and led to the identification of a family of serotonin-incorporating MOGLs as the...

The pathway reaction map depicts molecular events induced through serotonin-serotonin receptor interaction. Pathway map represents protein-protein associations, enzyme catalysis reactions, translocation events, gene and/or protein regulation induced upon treatment with serotonin or …

Nov 23, 2024 · Serotonin regulates energy metabolism as modulated by gut microbiota. Serotonin exerts metabolic effects in both the CNS and peripheral tissues through distinct serotonin receptors.

Jul 30, 2023 · Serotonin activity is regulated by its rate of synthesis, release, and metabolism. The majority of serotonin is intracellular, allowing for relatively tight control of its concentration. Serotonin is stored in intracellular vesicles, enters the synaptic cleft after neuron depolarization, then binds to G-protein coupled receptors (GPCRs) on ...