Schizophrenia is a common and serious psychiatric illness with strong evidence for genetic causation, but no specific loci yet identified. Chromosomal abnormalities associated with schizophrenia may help to understand the genetic complexity of the illness.

Oct 18, 2023 · Genetic findings have revealed the nature of schizophrenia’s close relationship to other conditions, particularly BD and childhood NDDs and provided an explanation for how common risk alleles...

Genetics constitute a crucial risk factor to schizophrenia. In the last decade, molecular genetic research has produced novel findings, infusing optimism about discovering the biological roots of schizophrenia.

The Epsin 4 gene on chromosome 5q, which encodes the clathrin-associated protein enthoprotin, is involved in the genetic susceptibility to schizophrenia. Am J Hum Genet. 2005;76:902–907. doi: 10.1086/430095.

Jan 27, 2016 · The site in Chromosome 6 harboring the gene C4 towers far above other risk-associated areas on schizophrenia’s genomic “skyline,” marking its strongest known genetic influence. The new study is the first to explain how specific gene versions work biologically to confer schizophrenia risk.

Jul 19, 2024 · In this Review, we describe what we now know about the genetics of schizophrenia and consider the neurobiological implications of this information.

Feb 26, 2025 · A research study has analyzed the relation between the genetic risk of having schizophrenia and mild subclinical traits in people of the general population. According to the study, the way the ...

2 days ago · Genetic Factors and Their Influence on Schizophrenia. Genetics tell another part of the story. Certain genes have been identified as potential risk factors, each playing a different role in brain development and function. DISC1, for example, is a key player in neurodevelopment and Wnt signaling, while Akt influences cell survival and neural ...

2 days ago · Genetic mutation linked to schizophrenia in both humans and mice; Diabetes drugs may boost brain health but experts warn of risks; Advanced software improves cerebellum analysis for disease diagnosis;

Mar 17, 2025 · Schizophrenia is a highly heterogeneous neuropsychiatric syndrome that is likely initiated by early brain developmental abnormalities caused by both genetic and environmental factors ...