Drugs that reduce the binding of serotonin to transporters (serotonin reuptake inhibitors, or SRIs) are used to treat mental disorders. The selective serotonin reuptake inhibitor (SSRI) fluoxetine …

A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the …

Sep 21, 2021 · Brain imaging techniques enable the visualization of serotonin transporter (SERT) occupancy as a measure of the proportion of SERT blocked by an antidepressant at a given …

As discussed previously, inhibition of presynaptic SERT causes an increase in serotonin at the synaptic cleft leading, in part, to the therapeutic effects of SSRIs and other antidepressants. …

Brain imaging techniques enable the visualization of serotonin transporter (SERT) occupancy as a measure of the proportion of SERT blocked by an antidepressant at a given dose. We aimed …

Sertraline and fluoxetine are selective serotonin reuptake inhibitors (SSRIs) widely-prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma membrane …

Aug 26, 2005 · However, the variability of estimated occupancy values may be too high for critical assessment of occupancy of SERT by SSRI. Serotonergic brain regions play a crucial role in …

Mar 20, 2020 · SERT activity is modulated by antidepressants, e.g., S-citalopram and imipramine, to alleviate symptoms of depression and anxiety. SERT crystal structures reveal two S …

Feb 1, 2024 · Polymorphisms in SERT have been associated with changes in clinical responsiveness to SSRI and the severity of adverse effects (A Daud, 2017). It has been …

Dec 1, 1999 · To investigate functional changes in the brain serotonin transporter (SERT) after chronic antidepressant treatment, several techniques were used to assess SERT activity, …