Drugs that reduce the binding of serotonin to transporters (serotonin reuptake inhibitors, or SRIs) are used to treat mental disorders. The selective serotonin reuptake inhibitor (SSRI) fluoxetine and the tricyclic antidepressant (TCA) clomipramine are examples of serotonin reuptake inhibitors.

A serotonin reuptake inhibitor (SRI) is a type of drug which acts as a reuptake inhibitor of the neurotransmitter serotonin (5-hydroxytryptamine, or 5-HT) by blocking the action of the serotonin transporter (SERT).

Sep 21, 2021 · Brain imaging techniques enable the visualization of serotonin transporter (SERT) occupancy as a measure of the proportion of SERT blocked by an antidepressant at a given dose. We aimed to...

As discussed previously, inhibition of presynaptic SERT causes an increase in serotonin at the synaptic cleft leading, in part, to the therapeutic effects of SSRIs and other antidepressants. SSRIs marked a massive improvement in the treatment of depression for many reasons, particularly their binding specificity.

Brain imaging techniques enable the visualization of serotonin transporter (SERT) occupancy as a measure of the proportion of SERT blocked by an antidepressant at a given dose. We aimed to systematically review the evidence on the relationship between antidepressant dose …

Sertraline and fluoxetine are selective serotonin reuptake inhibitors (SSRIs) widely-prescribed to treat depression. They exert their effects by inhibiting the presynaptic plasma membrane serotonin transporter (SERT).

Aug 26, 2005 · However, the variability of estimated occupancy values may be too high for critical assessment of occupancy of SERT by SSRI. Serotonergic brain regions play a crucial role in the modulation of emotion, and serotonergic dysfunction may contribute to …

Mar 20, 2020 · SERT activity is modulated by antidepressants, e.g., S-citalopram and imipramine, to alleviate symptoms of depression and anxiety. SERT crystal structures reveal two S-citalopram binding...

Feb 1, 2024 · Polymorphisms in SERT have been associated with changes in clinical responsiveness to SSRI and the severity of adverse effects (A Daud, 2017). It has been demonstrated that pregnant women treated with SSRI have an increased incidence of spontaneous abortion.

Dec 1, 1999 · To investigate functional changes in the brain serotonin transporter (SERT) after chronic antidepressant treatment, several techniques were used to assess SERT activity, density, or its mRNA content. Rats were treated by osmotic minipump for 21 d with the selective serotonin reuptake inhibitors (SSR …