Jul 13, 2017 · What is SLC6A4? The serotonin transporter, encoded by the SLC6A4 gene, is responsible for serotonin reuptake into the presynaptic neuron. While many antidepressants have some serotonin reuptake blocking activity, it is thought to be the major mechanism of action of the selective serotonin reuptake inhibitors (SSRIs).

The gene that encodes the serotonin transporter is called solute carrier family 6 (neurotransmitter transporter, serotonin), member 4 (SLC6A4, see Solute carrier family). In humans the gene is found on chromosome 17 on location 17q11.1–q12.

Dec 25, 2024 · SLC6A4 (Solute Carrier Family 6 Member 4) is a Protein Coding gene. Diseases associated with SLC6A4 include Obsessive-Compulsive Disorder and Anxiety. Among its related pathways are Transmission across Chemical Synapses and Nuclear receptors meta-pathway.

May 13, 2019 · Gene-by-environment interactions: Negative life events only lead to depression in individuals with a specific genetic set-up that makes them risk-prone to develop depression. The gene most commonly...

The human serotonin transporter (SERT) is encoded by a single gene (SLC6A4) located on the long arm of chromosome 17 (17q11-17q12).

SLC6A4 gene mutation is implicated in acute stress reactivity and response to antidepressants. Learn more about the role of genetic testing for medication.

Gene ID: 6532, updated on 8-Feb-2025. This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner.

SLC6A4 is a gene involved in regulating function of the serotonin system. Find out if your SLC6A4 gene is making you anxious or moody.

In this project we aimed to investigate the population genetic variation of the serotonin transporter gene (SLC6A4), focussing on the single nucleotide polymorphisms (SNPs). To this end, we employed 2504 individuals around the globe available in 1000 Genome project Phase III data and classified them into five ethnic groups: Americans (AMR ...

In vivo, SLC6A4 variants in humans and other species lead to marked physiological changes, despite mitigating neurodevelopmental adaptations in 5-HT receptors plus compensatory alterations in 5-HT synthesis and metabolism.

Feb 8, 2025 · Title: SLC6A4 gene variants moderate associations between childhood food insecurity and adolescent mental health. DNA methylation levels of the serotonin transporter gene are not associated with the outcome of highly standardized one …

Dec 2, 2010 · The SLC6A4 gene encodes the serotonin transporter, a membrane protein that takes up serotonin in pre-synaptic neurons. SLC6A4 is also known as SERT or 5-HTT, since serotonin is known chemically as 5-hydroxytryptamine.

May 10, 2012 · This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner.

Apr 1, 2013 · SLC6 transporters, which include the serotonin, dopamine, norepinephrine, GABA, taurine, creatine, as well as amino acid transporters, are associated with a number of human diseases and disorders making this family a critical target for therapeutic development.

Feb 11, 2021 · The serotonin transporter (5-HTT) encoded by SLC6A4 is a key molecule that regulates serotonergic neurotransmission at the synaptic cleft, affecting emotions and stress responses. Therefore ...

Feb 9, 2022 · The SLC6A4 Gene. If you have low-activity variants of SLC6A4, you are more sensitive to stress. This is because the SLC6A4 gene encodes a serotonin transporter protein. So a low-activity variant SLC6A4 may be the hidden culprit of your stress! When you’re stressed, cortisol floods your bloodstream. Cortisol then decreases serotonin signaling.

Separately, genetic association has been found between the SLC6A4 gene and pervasive developmental disorder (PDD) in a Dutch population cohort. In addition, rare mutations in the SLC6A4 gene have been identified in individuals with ASD (Neale et al., 2012).

Learn about the SLC6A4 gene; encodes for a protein that transports serotonin from the synapse back into the neuron to halt signaling.

Dec 1, 2016 · Findings revealed that SLC6A4 methylation has been investigated in humans in association with a number of prenatal and postnatal adverse exposures, encompassing maternal depression during pregnancy, perinatal stress exposure, childhood trauma and abuse, and environmental stress.

Jan 1, 2021 · One of the strongest candidates of depression genes is SLC6A4, which encodes a protein that is related to the transport of serotonin. The main purpose of this chapter is to explore the influence of genetic and epigenetic factors in SLC6A4 gene …