Combining p53 mRNA nanotherapy with immune checkpoint …
Feb 9, 2022 · As p53 loss of function may play a role in immunosuppression, we herein examine the effects of restoring p53 expression on the immune TME and ICB efficacy. We develop and …
The p53 mRNA: an integral part of the cellular stress response
We describe how the p53 mRNA affects post-translational modifications and the stability of the nascent protein as well as the expression of p53 isoforms with unique functions. Figure 1. Cell …
Targeting p53 pathways: mechanisms, structures and advances in …
Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss …
The p53 mRNA: an integral part of the cellular stress response
Apr 23, 2019 · The role of the p53 mRNA as a target for signalling pathways illustrates how mRNA sequences have co-evolved with the function of the encoded protein and sheds new …
Synthetic mRNA nanoparticle-mediated restoration of p53 tumor ... - PubMed
Dec 18, 2019 · Here, a redox-responsive nanoparticle (NP) platform is engineered for effective delivery of p53-encoding synthetic messenger RNA (mRNA). We demonstrate that the …
p53: updates on mechanisms, biology and therapy (I) - PMC
In a highly focused study, Fahreus and colleagues (Karakostis et al., 2019) describe how the interaction of p53 mRNA with the Mdm2 protein opens up new processes by which p53 …
Clinical and Immunological Effects of p53-Targeting Vaccines
TP53 gene encodes the transcription factor p53, one of the most important tumor suppressors. Under physiological conditions, p53 expression is tightly controlled and maintains a low level …
The multiple mechanisms that regulate p53 activity and cell fate
Mar 1, 2019 · Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and …
The p53 endoplasmic reticulum stress-response pathway evolved …
Feb 23, 2023 · The data show that the human p53 mRNA has evolved to respond to PERK-mediated regulation of mRNA structures in order to control p47 expression. The findings …
Therapeutic potential of combating cancer by restoring wild-type p53 …
Feb 1, 2024 · This review briefly discusses the role of p53 mutation in cancer and the therapeutic potential of restoring WTp53 through the advances in mRNA nanomedicine. Graphical …