Feb 9, 2022 · As p53 loss of function may play a role in immunosuppression, we herein examine the effects of restoring p53 expression on the immune TME and ICB efficacy. We develop and optimize a CXCR4-targeted...

We describe how the p53 mRNA affects post-translational modifications and the stability of the nascent protein as well as the expression of p53 isoforms with unique functions. Figure 1. Cell stress-dependent regulation of alternative initiation of p53 mRNA translation.

Mar 1, 2023 · Here, we provide a systematic review of the diverse molecular mechanisms of the p53 signaling pathway and how TP53 mutations impact tumor progression. We also discuss key structural features of...

Apr 23, 2019 · The role of the p53 mRNA as a target for signalling pathways illustrates how mRNA sequences have co-evolved with the function of the encoded protein and sheds new light on the information hidden within mRNAs.

Dec 18, 2019 · Here, a redox-responsive nanoparticle (NP) platform is engineered for effective delivery of p53-encoding synthetic messenger RNA (mRNA). We demonstrate that the synthetic p53 -mRNA NPs markedly delay the growth of p53 -null HCC and NSCLC cells by inducing cell cycle arrest and apoptosis.

In a highly focused study, Fahreus and colleagues (Karakostis et al., 2019) describe how the interaction of p53 mRNA with the Mdm2 protein opens up new processes by which p53 translation is controlled. Emphasizing the role of the RNA itself, they show profound effects of synonymous mutations in the coding region of p53.

TP53 gene encodes the transcription factor p53, one of the most important tumor suppressors. Under physiological conditions, p53 expression is tightly controlled and maintains a low level due to rapid degradation by the ubiquitin-mediated proteolysis.

Mar 1, 2019 · Activated p53 transcriptionally regulates hundreds of genes that are involved in multiple biological processes, including in DNA damage repair, cell cycle arrest, apoptosis and senescence.

Feb 23, 2023 · The data show that the human p53 mRNA has evolved to respond to PERK-mediated regulation of mRNA structures in order to control p47 expression. The findings highlight how p53 mRNA co-evolved with the function of the encoded protein to specify p53-activities under different cellular conditions.

Feb 1, 2024 · This review briefly discusses the role of p53 mutation in cancer and the therapeutic potential of restoring WTp53 through the advances in mRNA nanomedicine. Graphical abstract Restoring wild-type p53 activity may be a game-changer in multiple cancers.