The ubiquitin ligase COP1 regulates cell cycle and apoptosis by ...
Our results indicate that COP1 regulates human breast cancer cell proliferation and apoptosis in a p53-dependent manner. These findings suggest that COP1 might be a promising potential …
The ubiquitin ligase COP1 is a critical negative regulator of p53
May 6, 2004 · Here we identify the tumour-suppressor protein p53 as a COP1-interacting protein. COP1 increases p53 turnover by targeting it for degradation by the proteasome in a ubiquitin …
Spotlight on the role of COP1 in tumorigenesis - Nature
Jun 7, 2012 · The characterization of hypomorphic Cop1 mouse phenotypes provided evidence that COP1 targets JUN but not p53 for degradation in vivo and therefore acts as a tumour …
COP1, the Negative Regulator of p53, Is Overexpressed in Breast …
Oct 15, 2004 · Our analysis of both COP1 and p53 at the DNA, mRNA, and protein levels reveals that COP1 is overexpressed in breast and ovarian carcinomas suggesting that it may promote …
P53: Stability from the Ubiquitin–Proteasome System and Specific …
In 2004, transfection and binding assays in U20S cells (human female bone; source disease, bone osteosarcoma) indicated that p53 is a COP1 ligand. Subsequently, through miR-944 …
COP1, the negative regulator of p53, is overexpressed in
Oct 15, 2004 · We recently identified COP1 as a novel and critical negative regulator of p53. COP1 is a RING finger-containing protein that targets p53 for degradation to the proteasome …
Role of the COP1 protein in cancer development and therapy
Dec 1, 2020 · Accumulated evidence has revealed that COP1 is involved in carcinogenesis via targeting its substrates, including p53, c-Jun, ETS, β-catenin, STAT3, MTA1, p27, 14-3-3σ, …
COP1 – from plant photomorphogenesis to mammalian …
COP1-mediated p53 degradation is an important regulatory mechanism for p53 function in the cell. Overexpression of COP1, not its RING-finger mutant, inhibited p53-dependent apoptosis, …
Constitutive Photomorphogensis Protein1 (COP1) mediated p53 …
Feb 28, 2015 · COP1 is a negative regulator of p53 and acts as a pivotal controller of p53-Akt death-live switch (Protein kinase B). In presence of p53, COP1 is overexpressed in breast, …
The ubiquitin ligase COP1 is a critical negative regulator of p53
Apr 21, 2004 · Here we identify the tumour-suppressor protein p53 as a COP1-interacting protein. COP1 increases p53 turnover by targeting it for degradation by the proteasome in a...