Our results indicate that COP1 regulates human breast cancer cell proliferation and apoptosis in a p53-dependent manner. These findings suggest that COP1 might be a promising potential target for breast cancer-related gene therapy.

May 6, 2004 · Here we identify the tumour-suppressor protein p53 as a COP1-interacting protein. COP1 increases p53 turnover by targeting it for degradation by the proteasome in a ubiquitin-dependent fashion, independently of MDM2 or Pirh2, which are known to interact with and negatively regulate p53.

Jun 7, 2012 · The characterization of hypomorphic Cop1 mouse phenotypes provided evidence that COP1 targets JUN but not p53 for degradation in vivo and therefore acts as a tumour suppressor.

Oct 15, 2004 · Our analysis of both COP1 and p53 at the DNA, mRNA, and protein levels reveals that COP1 is overexpressed in breast and ovarian carcinomas suggesting that it may promote tumorigenesis by inactivating a p53-dependent pathway.

In 2004, transfection and binding assays in U20S cells (human female bone; source disease, bone osteosarcoma) indicated that p53 is a COP1 ligand. Subsequently, through miR-944 assays in HCT116 cells (human colon carcinoma), research groups showed that COP1 downregulation induces p53 activation and hence cell apoptosis.

Oct 15, 2004 · We recently identified COP1 as a novel and critical negative regulator of p53. COP1 is a RING finger-containing protein that targets p53 for degradation to the proteasome and is necessary for p53 turnover in normal and cancer cells.

Dec 1, 2020 · Accumulated evidence has revealed that COP1 is involved in carcinogenesis via targeting its substrates, including p53, c-Jun, ETS, β-catenin, STAT3, MTA1, p27, 14-3-3σ, and C/EBPα, for ubiquitination and degradation.

COP1-mediated p53 degradation is an important regulatory mechanism for p53 function in the cell. Overexpression of COP1, not its RING-finger mutant, inhibited p53-dependent apoptosis, whereas siRNA-ablation of COP1 led to p53 accumulation and cell-cycle arrest .

Feb 28, 2015 · COP1 is a negative regulator of p53 and acts as a pivotal controller of p53-Akt death-live switch (Protein kinase B). In presence of p53, COP1 is overexpressed in breast, ovarian, gastric cancers, even without MDM2 (Mouse double minute-2) amplification.

Apr 21, 2004 · Here we identify the tumour-suppressor protein p53 as a COP1-interacting protein. COP1 increases p53 turnover by targeting it for degradation by the proteasome in a...