The San Francisco 49ers got a taste of what their defense looks like without Nick Bosa in the second half of a loss to ...

The injury-prone San Francisco 49ers are monitoring yet another health issue, this one involving quarterback Brock Purdy's ...

If it wasn't clear before the Week 11 loss to the Seattle Seahawks, it is definitely clear now. The San Francisco 49ers are hungover from their Super Bowl loss ...

Meanwhile, Harbaugh is in Los Angeles, coaching the Chargers to a 7-3 record, with quarterback Justin Herbert looking like a ...

Star pass-catcher Jayden Reed and the Green Bay Packers play the San Francisco 49ers on Sunday at 4:25 p.m. ET, at Lambeau ...

One of the best pass-catchers in the NFL will be on show when Trey McBride and the Arizona Cardinals visit the Seattle ...

After falling to 5-5 with a disappointing 20-17 loss to the Seattle Seahawks on Sunday, the San Francisco 49ers received even ...

What are the lines we're looking at before movement later in the week? Here are some early picks for Week 12 of the NFL and ...

Technically, you could blame the defense for the 49ers' 20-17 loss to the Seahawks on Sunday because the defense couldn't close out the game. It gave up an 80-y ...

With a devastating loss in Week 11, the 49ers’ two-game win streak came to an end as they fell to 5-5 and to last place in ...

The San Francisco 49ers will conduct three full practices this week in preparation for their Week 11 matchup against the ...

As the San Francisco 49ers returned to the field against the Seattle Seahawks on Sunday, George Kittle 's wife, Claire Kittle ...