Shanghai Yiweikang Pharmaceutical Co. Ltd. has divulged camptothecin derivatives acting as DNA topoisomerase I inhibitors reported to be useful for the treatment of cancer. DNA topoisomerase I ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA. The finding ...

DNA topoisomerase 1 is an enzyme present in all organisms, essential for cell proliferation. Its function is based on two catalytic steps: firstly, it cuts and then relinks the DNA, thus relaxing ...

significantly raising the likelihood of encounters between replisomes or transcription complexes and topoisomerase-DNA complexes (TOPCCs). These encounters led to the formation of abortive TOPCCs ...

The board of directors (the “Board”) of the Company is pleased to announce that, recently, the first patient has been dosed in a phase 2 clinical study of HLX43 for injection (antibody-drug conjugate ...

Circulating tumor cells and tumor DNA in patients with resectable colorectal liver metastases: The MIRACLE. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract does not ...

Hemay181: A novel SDC (sugar linked drug conjugate) for solid tumors targeting tumor microenvironment. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract does not ...

Several research studies have examined the activities of salvicine on topoisomerase II (Topo II ... salvicine mostly decreases the catalytic activity with a negligible DNA breakage effect, as revealed ...

Topoisomerase II (TOP2) unlinks chromosomes during vertebrate DNA replication. TOP2 “poisons” are widely used chemotherapeutics that stabilize TOP2 complexes on DNA, leading to cytotoxic DNA breaks.

Here, we show that targeting ATM, but also ATR or DNA topoisomerases, results in the widespread aggregation of a metastable, disease-associated subfraction of the proteome. Aggregation-prone model ...