The bisphosphonates Aredia and Zometa and the monoclonal antibody denosumab can reduce the risk of fractures. Both classes of medications carry a small risk of osteonecrosis of the jaw.

Osteonecrosis of the jaw has been reported ... treat Paget's disease or malignancy-associated hypercalcemia (DIDRONEL, ZOMETA, SKELID, and their generic products). Bisphosphonates were first ...