Mediar Therapeutics has dosed the first subject in the Phase II WISPer trial of its investigational therapy, MTX-463, for ...

At the core of the deal is MTX-463, a potentially first-in-class human IgG1 antibody that targets and neutralizes the WNT1-inducible signaling pathway protein-1 (WISP1). Typically excreted into the ...

VANCOUVER, BC, Nov. 25, 2024 /PRNewswire/ -- Jiva Technologies (CSE: JIVA) (Frankfurt: WNT1) (OTCQB: PLTXF) ("JIVA" or the "Company"), a leader in building niche ...

Overexpression of miR-650 increased cell proliferation but suppressed apoptosis and inflammation of SW1353. As the target gene of miR-650, WNT1 overexpression counteracted the role of miR-650 in the ...

By creating multiple conditional mouse mutants, the authors demonstrate these cells are a distinct population from the previously reported ENCDCs which originate from the Vagal neural crest cells and ...

The breast cancer-derived 5a-D-Luc-ZsGreen cells were transfected with Wnt1, Wnt3A, and Wnt5A expression vectors, producing stably highly expressing cells. These cells were intracardially transplanted ...

For instance, Ball notes that mutations in the Wnt1 gene, which appears in many animal species, were found to hinder wing growth in flies yet cause cancer in mice, suggesting that genes don’t ...

The DCPs antagonize Wnt3a while sparing Wnt1 signaling. Using PEG linkers with different geometries, we converted the Wnt3a antagonist DCPs to multivalent molecules that potentiated Wnt1 signaling by ...

We also determined that the mutant clefting phenotypes that correlated with reduced WNT signaling could be rescued by Wnt1 ligand overexpression in the ectoderm. Collectively, these findings highlight ...

AOPP-induced upregulation of Wnt1, p-GSK3β, β-catenin, and TCF4 was suppressed by downregulation of RAGE (Feng et al., 2020). Salt inducible kinase 1 (SIK1), a member of AMP-activated protein kinases ...

To evaluate the preventive effect of Wnt/β-catenin activation on AKI, mice were injected with 1 mg/kg hemagglutinin (HA)-tagged Wnt1 expression vector (pHA-Wnt1, Upstate Biotechnology) or empty vector ...