Frontiers10d
Single-Cell Multiomic Approaches Reveal Diverse Labeling of the Nervous System by Common Cre-Drivers
RNA sequencing of labeled cells at E9.5 reveals that Wnt1-Cre2 marks cells with neuronal characteristics consistent with neuroepithelial expression, whereas Sox10-Cre predominantly labels the ...
Frontiers10d
Intermediate Cells of Dual Embryonic Origin Follow a Basal to Apical Gradient of Ingression Into the Lateral Wall of the Cochlea
FIGURE 1. Neural crest contributions to the inner ear during embryonic development from E12.5 to E17.5. Lineage tracing of neural crest cells using Wnt1-Cre2 mice crossed to an EYFP reporter line was ...
eLife28d
Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for bone fragility
The paper presents a streamlined new approach for functional validation of genes known to underlie fragile bone disorders in a relatively high throughput, using CRISPR-mediated knockouts and a number ...
eLife23d
Genetic and pharmacologic alterations of claudin9 levels suffice to induce functional and mature inner hair cells
This valuable study reports the induction of supernumerary inner hair cells in the mouse cochlea upon reducing the expression level of a tight-junction protein (claudin-9) at developmental stages.
gut.bmj16d
StellaTUM: current consensus and discussion on pancreatic stellate cell research
14 Southern California Research Center for ALPD and Cirrhosis, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA The field of pancreatic stellate cell (PSC ...