On May 12, 2025, the U.S. Court of Appeals for the Federal Circuit issued a long-awaited decision in Regents of the University of California v.

Biogen and City Therapeutics, a privately held developer of RNA-based “trigger molecules,” announced a partnership to develop ...

The personalized CRISPR treatment could be the future of gene therapy, but hurdles remain before everyone has access.

The researchers previously demonstrated the use of CRISPR to cut cancer cells from mouse models in a cancer-cell-specific manner; however, this is the first time they have applied this technique to ...

In CRISPR/Cas-based diagnostic tests, guide RNAs bind pathogen DNA or RNA, triggering Cas enzymes to become active and cleave the reporter nucleic acids that fluoresce when cleaved. However ...

Furthermore, CRISPR-based therapies offer a novel approach to directly targeting viral RNA, providing a potential treatment for diseases that currently lack effective antiviral drugs. 4 In this ...

In most recent advancements, RNA editing uses the CRISPR-Cas13 system, a newer technique that was created specifically to help develop therapies that work with RNA. DNA editing is permanent, which ...

The authors do not work for, consult, own shares in or receive funding from any company or organization that would benefit from this article, and have disclosed no relevant affiliations beyond ...

The review paper "CRISPR Beyond: Harnessing Compact RNA-Guided Endonucleases for Enhanced Genome Editing," authored by Feizuo Wang from National University of Singapore, presents a comprehensive ...

Bridge RNA is a lot like the guide RNA (gRNA) component of CRISPR-Cas9 systems. However, rather than recognizing one strand of DNA at a time as CRISPR gRNA does, bridge RNA recognizes two—the ...

There are two parts to the standard CRISPR Cas9 protein. One part links up with a guide RNA molecule and seeks out any DNA that matches a certain section of the guide RNA. Because it is easy to ...

I think that part is potentially better than what we have right now in CRISPR-Cas9.” The origin of the bridge RNA technique helps explain how it stands apart from RNA interference and CRISPR and ...