This study reports important negative results by showing that genetic removal of the RNA-binding protein PTBP1 in astrocytes is not sufficient to induce their conversion into neurons, challenging ...

Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China ...

Our study provides compelling evidence that rotenone causes changes in gene expression, related to the immune system in the substantia nigra, and synapse dysfunction in the motor cortex.

Rats exposed to the pesticide rotenone showed long-lasting gene expression changes in brain regions linked to Parkinson’s disease. The substantia nigra showed immune activation, while the motor cortex ...

The neurons in the substantia nigra produce dopamine, which is a neurotransmitter that plays a vital role in controlling movement.

Healthy substantia nigra in a human brain. The substantia nigra plays an important role in reward, addiction, and movement. Degeneration of this structure is characteristic of Parkinson's disease.

For decades, the narrative around Parkinson’s disease treatment has focused primarily on dopamine replacement. The loss of dopaminergic neurons in the substantia nigra is well recognized and ...

The findings of two recent studies give hope that the disease could one day be reversed in humans—but experts warn that this complex disease will likely need multiple complementary treatments.

Parkinson's disease is characterized by the progressive degeneration of dopaminergic neurons in the substantia nigra (SN), which project to the striatum (ST) via the nigrostriatal pathway. The loss of ...

Midbrain dopamine (DA) neurons, located in the substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA), are essential for regulating movement, emotion, and reward processing.

In a healthy brain, many messages are sent back and forth between dopamine neurons in a region of the brain called the substantia nigra and the striatum.