In two studies of mice, a molecule called leukotriene helped trigger food-induced anaphylaxis. A drug approved for asthma — zileuton — diminished it.

POTENTIALLY deadly food allergies could be prevented by an asthma drug. The breakthrough could lead to new protection for millions, say scientists. Zileuton, an oral pill used to treat asthma, ...

Enjoying the outdoors carries the danger of running into nature's less-friendly side: toxic plants and animals.

Cells have evolved ingenious ways to defend themselves from viral attack. Research from The Wertheim UF Scripps Institute ...

New therapies harness the body’s cancer-fighting powers, but they don't work for everyone. UChicago experts aim to change ...

Learn more about a new breakthrough in the gut-brain axis that suggests our microbiome has a direct and instant influence on our brain.

Structural insights into STING give new ways to inhibit it Researchers have discovered a highly conserved posttranslational modification in the STING pathway that ...

The interaction between a common gene variant and gut microbes may trigger chronic inflammation in ulcerative colitis, new research suggests.

Additionally, inhibiting the cGAS pathway or knocking out STING effectively reduces PANoptosis and alleviates the pathology associated with SARS-CoV-2 and influenza A virus infection in mouse models.

In diseases due to exposure to toxic particles like gout, macrophages elicit separate pathways for inflammation and lysosomal function ...

Although STING signaling in most immune cells is pro-inflammatory, the researchers discovered that bacteria-related STING signaling in these gut ILC3s causes the immune cells to migrate to nearby ...