Sickle cell disease (SCD) altered CD8+ T-cell chromatin architecture, triggering ferroptosis and weakening antitumor immunity ...

Indaptus Therapeutics, Inc. (Nasdaq: INDP) ("Indaptus" or the "Company"), a clinical stage biotechnology company dedicated to pioneering innovative cancer and ...

The mouse-based study, published in the Journal of Experimental Medicine, uncovered a new way to enhance stem cell-like memory CD8+ T cells following vaccination, pointing to a future where more ...

These cDCs present brain-derived antigens to T cells sitting in the cervical lymph nodes. In ApoE4 carriers, CD8+ T cells more easily cross from the blood into the brain. In tauopathy mice, antigens ...

Loss of TNFR1 signaling can restore thymocyte (SP CD8 cells) numbers. Lack of TNFR1 signaling prevented the severe inflammatory lung disease manifestation in STING ki mice. However, it is important to ...

One type of T cell—known as a CD8—is constantly on the prowl in the human body in search of intruders that can cause infections and disease. CD8 T cells transform, or differentiate ...

Panel E shows the flow cytometric analysis of peripheral blood on day 162. Panel F shows the CAR+CD4−CD8− T-cell counts in peripheral blood (blue line) and bone marrow (purple stars ...

Based on the role of the key E3 ligase BFAR in CD8 + T cell function, the researchers applied deep learning combined with molecular simulation to screen a library of approximately 1,474,607 compounds.

Association of tissue microbiota with cancer stages in lung adenocarcinoma. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract does not include a full text component.

To examine the Mettl3-dependent epi-transcriptional regulation in effector CD8 T cells, this study combined transcriptome and m 6 A modification abundance analysis of effector CD8 T cells. The ...

The study, "Trans-vaccenic acid reprograms CD8 + T cells and anti-tumor immunity," was supported by the National Institutes of Health (grants CA140515, CA174786, CA276568, 1375 HG006827 ...