The move drew sharp criticism from medical and health experts. “Scrapping the fastest platform we have is a reckless move ...

Cells have evolved ingenious ways to defend themselves from viral attack. Research from The Wertheim UF Scripps Institute ...

In a discovery that could broaden access to next-generation biologic medicines and vaccines, researchers at the University of ...

Health Secretary Robert F. Kennedy Jr. has repeatedly questioned the safety of mRNA technology, which is used in the company’s shot.

Vigeneron GmbH has received IND approval from the FDA for VG-801, a novel mRNA trans-splicing gene therapy to treat Stargardt disease and other retinal dystrophies associated with mutations in the ...

We show that widespread splicing dysregulation in HD occurs in an early cell model of neuronal development. Importantly, we observe HD-associated splicing changes in our HD cell model that were also ...

We report here a sensitivity of the mRNA splicing machinery to phosphorylation changes in response to LB-100 in colorectal adenocarcinoma. We observe enrichment for differentially phosphorylated sites ...

Interestingly, they provide evidence that the export of splicing intermediates requires docking and subsequent undocking at the nuclear basket, a step possibly more critical than for regular mRNAs.

Thus, the authors address that FBXO24 modulates global mRNA levels by regulating piRNA-mediated MIWI function and splicing events in testicular haploid germ cells. This study is performed with various ...

Transporting mRNA from the nucleus to the cytoplasm, called mRNA export, relies on protein complexes involving RNA helicases such as UAP56. Despite its near-identical nature, URH49 forms a ...