Department of Cardiology, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute, Renji Hospital, School of Medicine, Shanghai Jiao Tong ...

Role of SIRTs in Vascular Cells Since the first description of the role of SIRT1 in endothelial angiogenic function, 13 SIRTs have been identified in all types of vascular cells and found to regulate ...

MANILA – The Philippine Economic Zone Authority (Peza) has approved P52.93 billion worth of investment pledges in the first two months of the year. PEZA reported Tuesday that its investment ...

Figure 8: Regulation of ALDH3A1 and NECTIN4 by p53. Researchers Jessica J. Miciak, Lucy Petrova, Rhythm Sajwan, Aditya Pandya, Mikayla Deckard, Andrew J. Munoz, and Fred Bunz from the Sidney ...

A new research paper was published in Oncotarget, Volume 16, on February 18, 2025, titled "Robust p53 phenotypes and prospective downstream targets in telomerase-immortalized human cells.

One such mechanism involves a protein called p53. Often dubbed the "guardian of the genome," this protein plays a pivotal role in ensuring that your cells grow, divide and die in an orderly fashion.

Urtatiz and colleagues propose that gain-of-function mutations affecting the G-α-q signaling pathway are not tolerated in melanocytes residing in the interfollicular epidermis because of paracrine ...

No significant difference was found between the OA and LD groups (p > 0.05). The expressions of SIRT1 and p53 detected by western blot were consistent with the aforementioned findings. Therefore, ...

Although heterogeneity is recognized within the murine satellite cell pool, a comprehensive understanding of distinct subpopulations and their functional relevance in human satellite cells is lacking.

HepG2 cells treated with quercetin showcased increased p53 expression, miR-34a activity, and SIRT1 inhibition (140, 141). SIRT1 deacetylates p53, resulting in the cessation of its activity. miR-34a ...