Unlike cell wall inhibitors like penicillins, quinolones target bacterial DNA gyrase and topoisomerase IV, enzymes that are essential for DNA replication. By binding to these enzymes, quinolones ...

Urinary tract infections (UTIs) are among the most common bacterial infections, affecting millions worldwide. However, the increasing resistance of bacteria to standard antibiotics has made ...

Interdisciplinary research approach enables breakthrough Hauck and Böttcher's teams have now been able to identify new substances from the group of alkyl quinolones (AQs) that are even effective ...

Hauck and Böttcher's teams have now been able to identify new substances from the group of alkyl quinolones (AQs) that are even effective against multidrug resistant gonococci. AQs are substances ...

Gepotidacin is an oral, first-in-class triazaacenaphthylene antibiotic that inhibits bacterial DNA replication by blocking 2 different type II topoisomerase enzymes. Study participants were ...

Quinolones are widely used antibiotics that work by targeting the enzyme DNA gyrase which is essential to bacterial survival. Understanding the resistance mechanisms evolved by pathogens against ...

Second, "quinolone antibiotics are highlighted as positive here, as if they were less problematic for patients trying to have children," he criticized. Quinolone antibiotics are generally "frowned ...

quinolones; chicken; fowl typhoid; antimicrobial susceptibility; Salmonella. Evaluation of susceptibility to fluoroquinolones of S. Gallinarum from outbreaks in Korea, showed no resistance to this ...

Interaction explained: Methylprednisolone and quinolone antibiotics can both cause tendon problems, in particular, rupture of the Achilles tendon. Taking these drugs together can increase the risk ...

Suicide is one of the top causes of death in the U.S., with rates rising across the country. Nearly 46,000 Americans died by suicide in 2020, according to the CDC. Suicide can be preventable. And ...

Magnesium can interact with certain antibiotics, including tetracyclines such as Declomycin (demeclocycline), Vibramycin (doxycycline), and quinolone antibiotics such as Cipro (ciprofloxacin ...

However, numerous qnr (quinolone resistance) genes have now disseminated worldwide ... and proposed a model for how this interacts with type II DNA topoisomerases such as DNA gyrase, the cellular ...