Working model revealing the role of ALDH4A1 in maintaining an active MPC complex for mitochondrial pyruvate import and TCA cycle entry. Credit: Nature Cell Biology (2025). DOI: 10.1038/s41556-025 ...

CAMBRIDGE, Mass., May 14, 2025 (GLOBE NEWSWIRE) -- Agios Pharmaceuticals, Inc. (Nasdaq: AGIO), a leader in cellular metabolism and pyruvate kinase (PK) activation pioneering therapies for rare ...

The researchers identified the structure of this machine, the mitochondrial pyruvate carrier (MPC), and 50 years since its discovery, have shown how it operates like the lock on a canal to ...

Known as the mitochondrial pyruvate carrier, this molecular machine was first proposed to exist in 1971, but it has taken until now for scientists to visualise its structure at the atomic scale ...

Translocator is often used when your health is low during a dicey fight. CTRL ALT ESC is ideal for those moments, initiating health regeneration when teleporting at critical health.

"The Translocator setup allowed us to get a pure motor signal, a pure vestibular signal, and combined motor and vestibular signals. This meant that for the first time we were able to pull these ...

The Food and Drug Administration (FDA) has accepted for Priority Review the New Drug Application for SL1009 (sodium dichloroacetate oral solution) for the treatment of pyruvate dehydrogenase ...

Saol Therapeutics, a privately held, clinical-stage pharmaceutical company, announced today that the U.S. Food and Drug Administration (FDA) has accepted for review the New Drug Application (NDA ...

Pyruvate kinase deficiency has been identified in over 500 families. However, research shows that the condition could be highly underdiagnosed, as there is no way to identify mild cases.

This article reports that the DNA/RNA-binding protein Y-box binding protein 1 (YBX1) is localized to the mitochondrial inter-membrane space by its C-terminal domain (CTD) in cancer cells.

Translocator puzzle in The Talos Principle 2. (Image via Devolver Digital) Upon reaching the Southern Coastal region during the main campaign playthrough of The Talos Principle 2, you will come ...

Counterplay involving hunting the Translocator was rare, especially with reduced stun frequency in Overwatch 2. As the Stealth ability turns into a passive ability, Translocator now becomes a fast ...