Greatwall, a conserved MAST-like kinase with crucial mitotic entry functions, is curiously absent in worms. Here, the single ...

Over the past two decades, the idea of targeting transcription factors to combat malignancies has turned into a clinical reality.

Image supplied by WEHI. Calmodulin binds to PSKH1 (in grey) to 'switch on' PSKH1 activity. Reticulocalbin binds to PSKH1 to 'switch off' PSKH1 ...

Inhibition of nonsense-mediated decay turns immunologically cold tumors hot by increasing the amount of mutant RNA leading to an increase in T-cell-targetable neoantigens on the cell surface.

The US Food and Drug Administration has approved mirdametinib for the treatment of neurofibromatosis type 1 (NF1) in adults ...