She has investigated everything from primordial germ cells to oocytes and sperm, as well as the ovary and testis. She leads the Barton Lab, which explores how egg and sperm precursors fulfill their ...

After birth, oocytes are maintained in a dormant state in the primordial follicle, which is the most premature follicle in the ovary, and some are activated to form mature oocytes. Thus, regulation of ...

Crucial to embryo production is the availability of oocytes (egg cells ... to create induced pluripotent stem cells (iPCSs), primordial germ cells and finally artificial gametes.

Crucial to embryo production is the availability of oocytes (egg cells ... to create induced pluripotent stem cells (iPCSs), primordial germ cells and finally artificial gametes.

Later, they turned to human early oocytes (also known as primordial oocytes) to test their hypotheses, due to the difficulty of obtaining human samples. First, cells were labeled with a probe that ...

Over the ensuing 10 days, about 4–6 labeled germ cells from the clone survived to become oocytes within 4–6 individual primordial follicles. Closer study showed that the initial cyst first fragmented ...

Once activated, a primordial follicle grows in size and complexity as it progresses to primary, preantral, and antral stages, adding layers of granulosa and theca cells and forming an antral cavity, ...

From birth, females possess a limited number of primordial follicles, collectively called the ovarian reserve. Within each follicle is an oocyte that eventually becomes an egg. But with age, the ...

All oocytes in primordial follicles pause their development when the ovarian reserve is established and can stay in this paused state for decades. Namekawa said, “These arrested oocytes support ...

Propagating future generations depends on this reserve of pre-egg cells, or “primordial oocytes,” staying alive and out of the way of harmful, mutation-causing molecules — sometimes for ...