A new FEBS Letters review explores the dual role of autophagy in cancer and protein misfolding diseases—highlighting its ...

Researchers found that chronic sucralose exposure in male rats disrupted reproductive hormones, damaged sperm, and impaired ...

The tagged junk and p62 are then both broken down by autophagy. The accumulation of this protein suggests that autophagy wasn’t working properly. Elevated p62 levels were seen alongside a rise ...

It is known that autophagy-deficient macrophages have significantly increased levels of the chaperone protein p62. Since p62 binds polyubiquitinated proteins and facilitates their turnover via ...

p62 phosphorylation increased and poly-GA aggregates fell. Not so if Shao overexpressed R228H-TBK1, a partial-loss-of-function variant linked to ALS. This defunct version failed to rouse autophagy or ...

A groundbreaking study reveals the crucial role of the protein p62 in reducing neurodegenerative disorders through selective autophagy. Cells use selective autophagy or self-degradation of undesired ...

Previous studies have reported that the abnormal accumulation of the tau proteins may be selectively suppressed by autophagy pathways, through the p62 receptor protein (which is a selective ...

In a recent breakthrough, however, a study done by scientists at the National Institutes for Quantum Science and Technology in Japan proved the critical role played by a certain gene—the p62 gene—in ...

The autophagosome sequesters cytoplasmic cargo recruited by LC3-II, which interacts directly with cargo or indirectly through autophagy receptors, including p62, as shown in the magnified image.

This study aimed to investigate the effect of SQSTM1/p62, a multifunctional receptor, on biological function and autophagy characteristics in the human PTC cell line TPC-1. Results: Overall, p62 ...

The protein p62, a selective autophagy cargo receptor, plays a major role in clearing misfolded tau proteins and dysfunctional mitochondria, the energy powerhouse in all cells including neurons.