We show that production of cardiomyocyte NADPH, a key factor in redox regulation, is decreased in pressure overload-induced heart failure. As a consequence, the level of reduced glutathione is ...

The thioredoxin (Trx) system comprising NADPH, thioredoxin reductase (TrxR), and Trx and the glutathione (GSH) system composed of NADPH, glutathione reductase, and GSH supported by glutaredoxin are ...

There’s one in particular that has a lot of buzz surrounding it right now: glutathione. It’s been dubbed the “master antioxidant,” and everyone is raving about glutathione benefits.

A key molecule central to both processes is NADPH, which is produced by reduction of NADP+ during nutrient catabolism and which in turn drives the reduction of components such as glutathione and ...

Previous research recognizes that NADPH can produce reduced glutathione (GSH) as a coenzyme and produce ROS as a substrate of NADPH oxidase (NOX). Besides, excessive activation of glutamate receptors ...

Dietary magnesium treatment improved mitochondrial ATP synthesis and the NADPH‐dependent glutathione redox system in HGPS mice. Magnesium acted as an antioxidant in mitochondria, thereby reducing the ...

Department of Life, Health and Environmental Sciences, University of L’Aquila, 67100 L’Aquila, Italy ...

Pyruvate carboxylation to malate through elevated ME1 (malic enzyme 1) consumes NADPH necessary for reduction of glutathione and maintenance of intracellular redox state. Interestingly, our laboratory ...

Glutathione reductase converts GSSH back to GSH to complete the cycle, which is repeated as needed. An alternative pathway for reducing GSSH utilizes thioredoxin reductase along with thioredoxin (Trx) ...

Phase II enzymes including NADPH: Quinone Oxydoreductase 1 (NQO1) and Glutathione-S-Transferase (GST) represents a major and natural cellular protection system against deleterious environmental ...