The axolotl is renowned for its extensive ability to regenerate organs and body parts, including its spinal cord. Studies on spinal cord regeneration, however, have focused on axolotl cells next to an ...

CRISPR-edited iPSCs uncover early mitochondrial defects shared across ALS mutations, revealing pathways that could guide future treatments.

A neuroscience breakthrough has been achieved using AI to identify neuron cell types from the brain activity recordings of mice and monkeys with high accuracy.

Neurizon’s MD emphasised the company remained committed to advancing NUZ-001 as an effective potential treatment for amyotrophic lateral sclerosis/motor neurone disease (ALS/MND) and other ...

Thus, segment-specific axon guidance diversifies the function of homologous ... tub-LexA (Targets all cell (Lai and Lee, 2006). Used to image motor neuron activity in ex vivo preparation. Gift from Dr ...

Lower motor neuron (LMN) syndromes are clinically characterised by muscle atrophy, weakness and hyporeflexia without sensory involvement. They may arise from disease processes affecting the anterior ...

namely the robust segmentation of the neuron volumes from their surroundings with the simultaneous partitioning into their compartments, namely the soma, axon, and dendrites. We use the idea of ...

Each neuron has an axon that directly connects it with another ... cause the progressive destruction of the myelin sheath, resulting in the loss of motor function as axons "misfire." The loss of ...

and functional changes in the axon initial segment (AIS) drive abnormal neuronal excitability. This is the first study to pinpoint the role of AIS, a specialised region of motor neurons, in ALS ...

ALS, also known as motor neuron disease, causes progressive degeneration ... They examined how these mutations affect the axon initial segment, the region where electrical signals in neurons ...

This further suggests that degeneration starts in one type of motor neuron and, thereafter ... They further found that TDP-43 was transported along the axons and transferred to the ...

Motor — carry signals from the ... Once this threshold is exceeded, the neuron is triggered to send an impulse along its axon — this is called an action potential. An action potential is ...