Gear-obsessed editors choose every product we review. We may earn commission if you buy from a link. Why Trust Us? Until now, cells dividing by mitosis were thought to grow round and then split ...

a cytosolic DNA sensing pathway, which activates the innate immune response in the case of infection or if DNA is present in the cytosol due to DNA damage (e.g., mitochondrial damage, micronuclei, ...

Get Instant Summarized Text (Gist) Cells use the cGAS-STING-IRF3 pathway to detect aberrant DNA, signaling immune responses to infections, cell death, and cancer. A novel fluorescent biosensor has ...

We propose that whole-arm losses are immediate consequences of most centromere breaks, and others with partially intact centromeres form micronuclei, where they undergo S-phase replication and ...

Ultrafine Anaphase Bridges -- A Hidden Threat to Our ... the formation of small DNA-containing structures called micronuclei, and activation of the cell's emergency response systems, which ...

Epub 2025 Jan 8. PMID: 39779849 Agustinus A,…David Y#, Bakhoum S#. Epigenetic dysregulation from chromosomal transit in micronuclei. Nature. 2023 Jul;619(7968):176-183. doi: 10.1038/s41586-023-06084-7 ...

The in vivo studies are also promising, in that metformin reduced the number of micronuclei in bone marrow cells, which are indicators of DNA damage or genomic instability. Additionally, the treatment ...

The studies explain in mechanistic detail how micronuclei rupture and collapse in cancer cells, an important process that drives cancer progression. By getting tangled with mitochondria ...

Early [18F]FDG PET/CT response evaluation after a single dose of anti-EGFR therapy as a predictive biomarker for treatment benefit in patients with advanced colorectal cancer. This is an ASCO Meeting ...

The use of micronuclei DNA from erythrocytes for the detection of early-stage gastrointestinal cancers. This is an ASCO Meeting Abstract from the 2024 ASCO Annual Meeting I. This abstract does not ...

Cells have a variety of ways to repair different errors that can arise in DNA. Micronuclei, for example, contain genetic material that should be sequestered in the nucleus, but has been misplaced. The ...