Patient-Reported Outcomes During Pelvic Radiation Therapy: A Secondary Analysis on Sexual Function From NRG-RTOG 1203 The mammalian target of rapamycin (mTOR) inhibitor everolimus is US Food and Drug ...

Objectives Several therapies are used for the treatment of rareautoinflammatory conditions like cryopyrin-associated periodic fever syndromes (CAPS), hyperimmunoglobulin Dsyndrome (HIDS)/mevalonate ...

gaslini.org Background Different diagnostic and classification criteria are available for hereditary recurrent fevers (HRF)—familial Mediterranean fever (FMF), tumour necrosis factor ...

What Is Mevalonate Kinase Deficiency? Mevalonate kinase deficiency (MKD) is a disease that runs in families. A problem with your immune system causes attacks of fever and symptoms like swollen ...

Dosage for hyperimmunoglobulin D syndrome/mevalonate kinase deficiency (HIDS/MKD) For adults and some children with a body weight greater than 40 kg, the recommended starting dosage of Ilaris for ...

A creatine kinase test is a blood test that measures levels of an enzyme called creatine kinase. This enzyme supports energy production in the body and is particularly important for muscle and ...

Mevalonate kinase deficiency (MKD), a rare auto-inflammatory disorder, arises from mutations in the MVK gene, disrupting isoprenoid biosynthesis, and affecting cellular processes. This comprehensive ...

Inhibition of mevalonate synthesis by statins decreases geranylgeranyl (GG) pyrophosphate and prevents the geranylgeranylation of Rho and therefore its activation of Rho kinase (ROCK). ROCK mediates ...

It’s also called hyper-IgD syndrome, or HIDS. It’s a less severe form of a metabolic disorder called mevalonate kinase deficiency (MKD). HIDS is something you’re born with. Symptoms ...

Cryopyrin-associated periodic syndromes (CAPS), familial Mediterranean fever (FMF), tumour-necrosis factor receptor-associated periodic syndrome (TRAPS) and mevalonate-kinase deficiency ...

Hyper IgD syndrome (HIDS)—also known as mevalonate kinase deficiency (MKD)—is caused by an inherited recessive gene mutation of the mevalonate kinase gene (MVK). MVK is an enzyme involved in ...