The study tracks the natural cycles of the planet’s climate over a period of a million years. Their findings, published in Science, offer new insights into Earth’s dynamic climate system and represent ...
The study tracks the natural cycles of the planet's climate over a period of a million years. Their findings offer new insights into Earth's dynamic climate system and represent a step-change in ...
Whilst the ultimate outcome of the lytic cycle is production of new phage progeny and death of the host bacterial cell, this is a multistep process involving precise coordination of gene transcription ...
Because phages exert pressure on the bacteria they infect and some phage genomes encode virulence factors and toxins, a role for specific phages or communities of phages in human health seems ...
that differs only in two amino acids to test if those mutations altered phage infection parameters such as the length of the phages lytic cycle, burst size and host range. Moreover, we sought to ...
Thus, the formation of a true plaque demonstrates that the phage is not only able to undergo all steps of the lytic cycle, but that the cycle is able to continue in a self-supplying way. The titration ...
because its concentration after dilution is much lower than the response threshold θ of the phage variants that are selected. Evolved phages switch from the lytic to the lysogenic life-cycle when ...
Herpesviral lytic gene functions render the viral genome susceptible to novel editing by CRISPR/Cas9
CRISPR/Cas9 induces indel mutations in HSV-1 genomes during lytic replication To define the mechanisms of CRISPR-Cas9 editing of lytic genomes, we analyzed the effect of SaCas9/sgRNAs on lytic viral ...
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