Lysosomes are membrane-bound organelles, which contain, among other components, hydrolytic enzymes that operate in an acidic environment (Sabatini and Adesnik, 2014). Lysosomes are capable of ...

Herein, we demonstrate that isomerization and epimerization, which are spontaneous chemical modifications that occur in long-lived proteins, prevent digestion by the proteases in the lysosome (namely, ...

Here, we develop a genetic toolkit that facilitates analysis of early endosomes and lysosomes in stem cell-derived neurons and demonstrate its utility in defining the landscape of endocytic cargo in ...

Here’s how it works. A newly discovered house-size asteroid is set to make a close, yet harmless approach to Earth today (May 21), passing within one-third of the Earth-moon distance.

Alternatively, they are segregated in ER subdomains that are shed from the biosynthetic compartment and are delivered to endolysosomes under control of ER‐phagy receptors for ER‐to‐lysosome‐associated ...

Grain size is an important agronomic trait and influences both grain yield and quality in crops. The atypical heterotrimeric Gγ protein subunit GS3 is a central regulator of grain length in rice, and ...

Lysosome-related organelles (LROs) or granules are the main protease storage and processing organelles of the endolysosomal system. The range of proteases present in LROs is cell-type specific.

Part of the ATI is an ordered reduction in the fleet size for the High Accuracy Detection and Exploitation System (HADES) to six, officials have confirmed. The direction states the planned fleet ...

State Key Laboratory of Swine and Poultry Breeding Industry, South China Agricultural University, Guangzhou, Guangdong 510642, China Guangdong Academy of Agricultural Sciences, Guangzhou, Guangdong ...