The highly diastereoselective oxy-Michael addition of the “naked” anion of (6S)-methyl δ-lactol to γ-substituted β,γ-unsaturated α-keto esters leading to the direct formation of THP*-protected ...

Chemistry Process Research and Development, Amgen Inc., Thousand Oaks, California 19320, Medicinal Chemistry, Amgen SF, South San Francisco, California 94080, Process ...