Nuvation Bio Inc. (NYSE: NUVB), a global oncology company focused on tackling some of the toughest challenges in cancer ...

Sibeprenlimab clinically reduces proteinuria in adults with immunoglobulin A nephropathy (IgAN), according to data from a prespecified analysis of the phase 3 VISIONARY trial. The findings were ...

Liver fibrosis often develops without symptoms and has no approved cure. But researchers at the University of Sunderland have ...

Asandeutertinib is a derivative of Tagrisso designed to avoid certain toxic side effects in patients with EGFR-mutated NSCLC.

Insilico’s drug, ISM001-055, targets and inhibits Traf2- and Nck-interacting kinase (TNIK), an enzyme that plays a role in signaling pathways associated with disease. While TNIK inhibition has ...

The novel compounds block or inhibit an enzyme ... LSD1 inhibitors are in clinical trials for solid tumors. However, few of them interact with LSD1 in a reversible manner. Irreversible drugs ...

ITC approaches have been developed to measure reversible and irreversible enzyme inhibition, the effects of molecular crowding on enzyme activity, the activity of immobilized enzymes and the ...

Moreover, these enzymes are involved in the disruption of normal lung ... groups (carbamate and triazole urea), and demonstrate their function as potent, irreversible inhibitors of trypsin and TLPs, ...

irreversible menin inhibitor designed to control menin’s negative impact across several indications FIH Study will initially enroll patients with relapsed/refractory acute leukemia, with additional ...