Kuhn and her colleagues propose that blocking indole production or shifting tryptophan metabolism toward anti-inflammatory pathways could provide relief.

These findings not only position pyruvate as a potential novel oral therapy for ulcerative colitis but also highlight the therapeutic relevance of targeting cPLA2 in inflammatory bowel diseases. By ...

In vitro and in vivo experiments demonstrated that Halicin could activate pyruvate kinase M2 from its inactive dimers to active tetramers, changing the metabolism of tumor cells and suppressing tumor ...

Our approach resulted in the formation of five clusters of cells that displayed different ratios of metabolites of glycolysis, pentose phosphate pathway, pyruvate-TCA cycle, proline metabolism, serine ...

A significant subset of the so-called prenylated indole alkaloids (PIAs) contains an angularly fused pyrano[2,3-g]indole core, while a smaller number embody the isomeric and linearly fused ...

Concomitantly, IFN-γ triggers indoleamine 2,3-dioxygenase 1 (IDO1) and Interleukin-4 induced 1 (IL4i1), resulting in the conversion of tryptophan into kynurenine and indole-3-pyruvic acid. These ...

However, IDO (Indole 2,3 dioxygenase) blockers which inhibit tryptophan metabolism to kynurenine failed to show benefit in clinical trials, suggesting the presence of alternate AhR activation. We ...

Importantly, we revealed that the gut microbiota fermented inorganic CNMs as a bioavailable carbon source into organic butyrate through the pyruvate pathway during CNMs fermentation, which serves as a ...