Find more information on the Altmetric Attention Score and how the score is calculated. Imatinib, a drug used for the treatment of chronic myeloid leukemia and other cancers, works by blocking the ...

Here, we develop a genetic toolkit that facilitates analysis of early endosomes and lysosomes in stem cell-derived neurons and demonstrate its utility in defining the landscape of endocytic cargo in ...

Metastasis of cancers accounts for almost all cancer-related deaths. In this study, we report a PEGylated nanostructured platform for coadministration of doxorubicin (DOX) and imatinib (IMT) intended ...

It's also important to understand that all of the TKIs can harm a fetus if taken during pregnancy. Imatinib (Gleevec) was the first drug to specifically target the BCR-ABL tyrosine kinase protein, and ...

MC SGs belong to the family of lysosome related organelles (LROs), as indicated by their content of lysosomal hydrolases, lysosomal membrane proteins and acidic pH. The SGs derive from the Golgi and ...

GIST outpatients who received imatinib mesylate (Gleevec, Novartis, Switzerland) between July 2020 and March 2021 at the First Affiliated Hospital of Soochow University were selected. Upon enrollment, ...