A new FEBS Letters review explores the dual role of autophagy in cancer and protein misfolding diseases—highlighting its ...

Hypoxia decreases MHC-I expression in an oxygen-dependent manner, via activation of autophagy through the PERK arm of the unfolded protein response. Using an immunopeptidomics-based LC-MS approach, we ...

DEPP1 is both necessary and sufficient for hypoxia-induced autophagy and triglyceride accumulation in cardiomyocytes ex vivo. DEPP1 loss increases cardiomyocyte survival in the setting of chronic HIF ...

The Von Hippel–Lindau (VHL) protein, which is frequently mutated in clear-cell renal cell carcinoma (ccRCC), is a master regulator of hypoxia-inducible factor ... VHL suppresses nutrient ...

To address these issues, herein we developed surface-engineered chlorella (Chl, a green algae) as a targeted drug carrier and sustainable oxygen supplier (via photosynthesis) for significantly ...

ROC-325 attenuated high K + or alveolar hypoxia-induced pulmonary vasoconstriction and enhanced endothelial-dependent relaxation in isolated pulmonary artery rings. ROC-325 treatment inhibited ...

Autophagy is one of the adaptive responses to hypoxia with important implications for cell survival. While the autophagic machinery in DCs was shown to impact signaling of TLRs, its regulation by the ...

Hypoxia can also activate autophagy, by either hypoxia-inducable factor (HIF) pathway or HIF independent pathways. Hypoxia can promote ER stress, and mitochondria also have reduced function when ...

A constant oxygen supply is essential for cardiac viability and function. Hypoxia induces some pathological process, such as oxidative stress, autophagy and apoptosis [2] [3] [4] . To date, ...

HIF-1a can induce the expression of BNIP3 when the cell is hypoxic, and it is linked to various phenomena, such as autophagy mediated by hypoxia, cell survival mechanisms and progression of tumors 1.

Emerging data indicate that several factors, such as hypoxic stress, activate a plethora of resistance mechanisms, including autophagy, in tumor cells. Hypoxia-induced autophagy in the tumor ...