Recruitment of FAK is already defective at E16, however, and hair cells with abnormal or immature stereocilia accumulate between E18 and P0, during the peak times of stereocilia maturation.

Fintel reports that on September 30, 2024, Guggenheim initiated coverage of Verastem (NasdaqCM:VSTM) with a Buy ...

Fast Track Designation is available to drugs that may provide an advantage over current therapies in the treatment of serious conditions. It is designed to speed the development o ...

HIGHLIGHTS The US FDA has granted Fast Track Designation to Amplia's lead drug narmafotinib in advanced pancreatic cancer Fast Track Designation facilitates the development of investigational drugs an ...

Focal Adhesion Kinase (FAK) acts as a mediator in sustaining KRAS-driven lung tumors, and although FAK inhibitors are currently undergoing clinical development, clinical data indicated that their ...

The manuscript by Carbo et al. reports a novel role for the MltG homolog AgmT in gliding motility in M. xanthus. The authors provide convincing data to demonstrate that AgmT is a cell wall lytic ...

It is a small molecule administered through oral route. It acts by targeting focal adhesion kinase (FAK). The drug candidate was also under development for the treatment of triple negative breast ...

It is a new molecular entity (NME) with a structure based on a coumarin skeleton. The drug candidate acts by targeting B-Raf kinase, C-Raf kinase, mitogen activated protein kinase kinase 1 (MEK-1 or ...

Verastem’s Avutometinib and Defactinib combination therapy targets recurrent LGSOC and is expected to complete its rolling NDA by 2H2024. The company has a diverse pipeline, exploring treatments ...

WASHINGTON—In January 2023, a representative claiming to work with a European finance professional named Eduard Grigoriann shared instructions with a popular U.S. conservative media influencer ...

U.S. Vice President Kamala Harris faced criticism on social media for allegedly using a "fake accent" during a Labor Day rally in Detroit. Critics accused her of adopting a forced southern accent, ...