This peptide is part of the leukophilic IgG (residues 289–292) and binds specifically to macrophages, monocytes and polymorphonuclear leukocytes.

Foamy macrophages were initially identified as anti-inflammatory but have recently shown dual functionality, possibly depending on the disease stage and phenotype. Recent mouse and human studies also ...

Accumulation of macrophage foam cells in atherosclerotic lesions is the hallmark of early-stage atherosclerosis. 1,2 The formation of foam cells is due mainly to uncontrolled uptake of modified ...

BACKGROUND: Trem2 (triggering receptor on myeloid cells 2), a surface lipid receptor, is expressed on foamy macrophages within atherosclerotic lesions and regulates cell survival, proliferation, and ...

Atherosclerotic plaque formation is supported by the accumulation of cholesterol loaded foamy macrophages within the artery wall. Molecular regulators of foamy macrophage differentiation and survival ...

In atherosclerosis, macrophages can transform into the fat-laden "foam" cells, which are also known as lipid-associated macrophages (LAMs) and are a hallmark of atherosclerosis and other diseases ...

The significance of the new discovery is not just limited to the PAP disease. Bloated, foamy macrophages are also found in people with obesity or atherosclerosis.

Bloated, foamy macrophages are also found in people with obesity or atherosclerosis. "Maybe we can learn from alveolar macrophages in the lungs and translate our findings to other macrophages and ...

And foamy macrophages tend to encourage inflammation in the arteries and sometimes bust apart plaques, freeing clots that can cause heart attack, stroke or embolisms elsewhere in the body.

Although BAL differential cell counts and alveolar CD4/CD8 values were found to be consistent with those described in the literature, an increase in mast cells and the presence of foamy macrophages ...

AtheroSpectrum Reveals Novel Macrophage Foam Cell Gene Signatures Associated With Atherosclerotic Cardiovascular Disease Risk. Circulation, 2022; 145 (3): 206 DOI: 10.1161/CIRCULATIONAHA.121.054285 ...