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Eli Lilly pays $10m upfront for Organovo’s FXR agonist
Eli Lilly (Lilly) has agreed to make a $10m upfront payment for full worldwide rights to San Diego-based Organovo Holdings’ farnesoid X receptor (FXR) agonist programme, aimed at treating ...
News-Medical.Net on MSN12d
Novel cyclic peptide antagonist can be a promising therapeutic approach for MASH
The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism.
Yahoo Finance1mon
Why Eli Lilly Stock Popped Today
In one, Lilly announced plans to acquire the farnesoid X receptor (FXR) program of clinical-stage biotech Organovo (NASDAQ: ONVO), including its lead asset, FXR314, a drug that aims to treat ...
Medscape25d
The Vitamin D–antimicrobial Peptide Pathway and Its Role in Protection against Infection
xenobiotic compounds and microbial byproducts can maintain critical gut immunity by inducing antimicrobial gene expression. FXR: Farnesoid X receptor; VDR: Vitamin D receptor; RXR: Retinoid X ...
FOX40 News17d
New Avenues for Treating Metabolic Dysfunction-Associated Fatty Liver Disease
Several transcription factors, including farnesoid X receptor (FXR), peroxisome proliferator-activated receptors (PPARs), thyroid hormone receptors (THRs), and liver X receptors (LXRs), have ...
EurekAlert!6mon
Potential candidates for MASLD and their mechanisms of action (IMAGE)
ACC, Acetyl-CoA Carboxylase; PPAR, peroxisome proliferator–activated receptor; MPC, mitochondrial pyruvate carrier; THR, thyroid hormone receptor; ASK-1, apoptosis signaling kinase-1; GLP-1R ...
Baylor College of Medicine2y
Clavia Ruth Wooton-Kee Lab
Our lab identified that excessive copper concentrations decreased metabolic nuclear receptor activity (FXR - farnesoid X receptor, HNF4a – hepatocyte nuclear factor, and LRH-1 – liver receptor homolog ...