The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism.

Ready to save your liver? Transcription factors are paving the way for metabolic dysfunction-associated fatty liver disease ...

Several transcription factors, including farnesoid X receptor (FXR), peroxisome proliferator-activated receptors (PPARs), thyroid hormone receptors (THRs), and liver X receptors (LXRs), have emerged ...

Metabolic dysfunction-associated fatty liver disease (MAFLD) has become a growing global health concern, affecting millions ...

HDAC, histone deacetylases; GPCRS, G protein-coupled receptors;SCFAS, short-chain fatty acids; TGRS, traditional gender roles; FXR, Farnesoid X receptor ;SABs, Secondary bile acids. Similar to the gut ...

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

xenobiotic compounds and microbial byproducts can maintain critical gut immunity by inducing antimicrobial gene expression. FXR: Farnesoid X receptor; VDR: Vitamin D receptor; RXR: Retinoid X ...

Eli Lilly (Lilly) has agreed to make a $10m upfront payment for full worldwide rights to San Diego-based Organovo Holdings’ farnesoid X receptor (FXR) agonist programme, aimed at treating ...