Experts explain what we know about the connection between gallstones and MASLD, and what you can do to reduce the risk of ...

New research reveals that specialized gut bacteria convert bile acids into powerful healing compounds, offering hope for ...

The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism.

Modern structural analyses have revealed that these modifications significantly influence receptor binding affinity and specificity, particularly for key receptors such as FXR and TGR5 (2, 3). The ...

The research teams led by Kristina Schoonjans and Rizlan Bernier-Latmani at EPFL, have identified Clostridium scindens, a bacterium that converts primary bile acids into 7α-dehydroxylated bile ...

It has been shown that primary bile acids are capable of inducing cathelicidin gene expression in biliary epithelial cells through the FXR. Secondary bile acids that are byproducts of metabolism ...

Hyaluronic acid is an ingredient that’s talked about a lot, so finding the best hyaluronic acid serum – in which the star ingredient is concentrated – is an essential for plump, juicy and hydrated ...

Intercept Therapeutics’ efforts with FXR agonist Ocaliva (obeticholic acid) ended in disappointment when the US Food and Drug Administration (FDA) rejected the drug for MASH in 2023, forcing the ...