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Novel cyclic peptide antagonist can be a promising therapeutic approach for MASHThe farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism.
The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism. Bile acids are natural ligands of FXR, which bind to the ...
The farnesoid X receptor (FXR) is a bile acid nuclear receptor that plays a crucial role in regulating bile acid and sterol metabolism. Bile acids are natural ligands of FXR, which bind to the ...
It has been shown that primary bile acids are capable of inducing cathelicidin gene expression in biliary epithelial cells through the FXR. Secondary bile acids that are byproducts of metabolism ...
Novartis has joined with Allergan in a bid to get ahead in the race to get a drug approved to treat the fatty liver disease, non-alcoholic steatohepatitis (NASH). The Swiss pharma said it is to ...
Primary BAs, i.e., cholic acid (CA) and chenodeoxycholic acid (CDCA), are synthesized ... These effects are mediated through the activation of nuclear receptors, such as farnesoid X receptor (FXR) and ...
Ipsen has taken rights to PPAR agonist elafibranor as a treatment for primary biliary cholangitis – a chronic, autoimmune disease in which bile ... Pharma's FXR agonist obeticholic acid ...
Modern structural analyses have revealed that these modifications significantly influence receptor binding affinity and specificity, particularly for key receptors such as FXR and TGR5 (2, 3). The ...
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