Innovative delivery techniques, including high-tech nanoparticles and electroporationdevices, may convey more gene therapies ...

To investigate how the oocyte controls activation of endosome and lysosome activity, Satouh et al. used live imaging techniques to observe mice oocytes as they matured, were fertilised and developed ...

IFITM3 interacts with SNARE proteins that mediate late endosome-late endosome (homotypic) fusion and late endosome-lysosome (heterotypic) fusion. IFITM3 binds to syntaxin 7 (STX7) in cells and in ...

We wish to particularly thank Unjal Pradhan for her hard work and invaluable aid with calculating Benchmarking Universal Single Copy Orthologs (BUSCO) scores, artistic modification of supplementary ...

Rab7 is well established as a regulator of multiple aspects of endolysosomal function including membrane traffic, endosome maturation and lysosome subcellular positioning (Kummel et al, 2023). Rab7 ...

The cells up- or down-regulated genes involved in endosome-lysosome function and repair, protein folding, and inflammation. They accumulated more protein after inhibition of the main disposal pathways ...

Cell-cell communication is an essential process in life, with endosomes acting as key organelles for regulating uptake and secretion of signaling molecules. Endocytosed material is accepted by the ...

decreased late endosome/lysosome number, and strongly inhibited proplatelet formation. These data support the interconnection of functional Rab5-mediated endosomal trafficking in the process of ...

When endocytic pathway was used during SARS-CoV-2 infection, SNX27-retromer sorts ACE2/SARS-CoV-2 complex at early endosome and prevents it from entering lysosome/late endosome, inhibiting the cell ...

To examine whether the expressions of 260 organelle crosstalk regulators (OCRGs) in 16 functional groups are modulated in 23 diseases and 28 tumors, we performed extensive -omics data mining analyses ...

In an ideal situation, the target antigen would only be expressed and of sufficient density on tumor cells, be rapidly internalized upon ADC binding, and efficiently trafficked to the endosome and the ...