(A) Relative urinary cystine concentration of Slc3a1 KO and WT mice from both sexes. (B) Typical hexagonal cystine crystals from the urine of Slc3a1 KO and WT mice. Scale bar,100 μm. (C ...

Progeny of the 2 founder lines were maintained as separate colonies and offspring were genotyped by Southern blot and polymerase chain reaction (PCR). Appropriate breeding generated mice homozygous ...

The Ca2+ stored in the cellular endoplasmic reticulum (ER) plays a crucial role in protein folding and lipid transfer, and its impairment leads to cellular ER stress. When chronic cellular ER stress ...

We conducted pharmacokinetic and toxicology studies on Quantum Dot 705 (QD705) in male ICR mice for up to 6 months after a single intravenous dose. Time-course sacrifices were carried out at 1, 4, and ...

In the years after the 2020 COVID-19 pandemic, it is clear that mRNA as a modality for vaccines and therapeutics is here to stay based on the number of mRNA programs currently in clinical development.

d) Representative images and statistical analysis of western blot analysis showing the expression level of GSDMD and caspase1 in dorsal skin of WT and GSDMD-KO ... Dot plot of Gsdmd expression in each ...

S6K1 is a protein involved in the regulation of aging and age-related diseases. Blocking this protein in mice makes them live longer and mimics the health benefits of reducing calorie intake ...

Emerging research highlights mice as a critical yet underestimated source of leptospirosis, emphasizing the need for improved strategies to control the spread of the infectious disease. Led by ...

2021). The cortex of 10-month-old PINK1 KO mice also showed reduced levels of mature and immature BDNF by western blot analysis. Cardiac hypertrophy was observed at 2 and 6 months of age, but not at 1 ...