The binding interactions of two antitumor agents that target the paclitaxel site, docetaxel and discodermolide, to unassembled α/β-tubulin heterodimers and microtubules have been studied using ...

"And if men with PSA <4 really benefit from docetaxel by decreasing prostate cancer deaths, and also benefit from having less radiation-induced cancers, that's a double win for those men." ...

No significant differences were found between groups (P>0.05; t-test). Results are reported as means±SE. DTX: docetaxel; MNT: montelukast. The administration of DTX resulted in a significant elevation ...

Department of Urology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P. R. China Jianian Hu and Xiaoguang Shao contributed equally to this work.

Datopotamab Deruxtecan Versus Docetaxel for Previously Treated Advanced ... Structure, Thermodynamics, and Kinetics of Plinabulin Binding to Two Tubulin Isotypes. Chem 2019; 5(11): 2969-2986.

PhD Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States Department of Chemistry and Biochemistry, Brooklyn College, The City ...

The adhesion of cells to the surrounding extracellular matrix and their stimulation by soluble growth factors provide the environmental cues necessary to control a cell's decision to survive ...

Inhibition of N-glycosylation or knockdown of ACTRIIB resulted in reduced cell proliferation and invasion and increased the cell sensitivity to docetaxel. In conclusion, N-glycosylation of ACTRIIB was ...

Other Recently Approved Agents (eg, gemcitabine and docetaxel) Mechanism of Action: These are chemotherapy agents. Gemcitabine works by inhibiting DNA synthesis in rapidly dividing cancer cells, while ...

It has been proposed to enable regeneration of damaged axons through its direct binding to the α/β tubulin dimer, an interaction that modulates microtubule assembly and/or dynamics. Here, we determine ...