Researchers at Duke University Medical Center and Wake Forest University School of Medicine have identified ALDH4A1, a ...

This valuable study focuses on defining how the HSP70 chaperone system utilizes J-domain proteins to regulate the heat shock response-associated transcription factor HSF1. Using a combination of ...

As part of their experiments, the researchers found that boosting ATP production using NMN rescued cytosolic fluidity by breaking up and solubilizing existing protein aggregates in axons from ALS ...

This work identifies βHB as a global regulator of cytosolic protein solubility, and identifies new metabolism-related mechanistic targets for therapeutic development in aging and AD.” ...

An article in Protein & Cell discusses the multifactorial ... The paper is titled "Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in mice." ...

we engineered bifunctional compounds that bind to proteins in separate cellular compartments. We show these compounds induce nuclear import of cytosolic cargoes, using nuclear-localized BRD4 as a ...

In the June 9 Cell, researchers led by Vikram Khurana at Brigham and Women’s Hospital, Boston, suggest as much, describing an unexpected role for α-synuclein in cytosolic mRNA processing bodies, a.k.a ...

Chaperones directly bind to the misfolded protein to counteract aggregation. The eukaryotic chaperone TRiC assists in correct folding of cytosolic protein substrates and prevents protein aggregation.

The translocase of the outer membrane (TOM complex) forms the entry gate for the vast majority of precursor proteins that are produced on cytosolic ribosomes. Surveillance of the functionality of ...

Mitochondria are organelles with their own genomes, but they rely on the import of nuclear-encoded proteins that are translated by cytosolic ribosomes. Therefore, it is important to understand whether ...