Cyclization is a promising strategy to enhance protein stability, but its applicability is often limited by structural constraints such as the distance between the N- and C-terminal regions. Here, we ...

Room-temperature phosphorescence (RTP) is a fascinating optical phenomenon, and a variety of methods have been developed to achieve and improve the desirable phosphorescent performance on demand.

To investigate how DNA mismatches affect the mechanical stability and the exposure of nucleosomal DNA, we used an optical trap combined with single-molecule FRET and a single-molecule FRET cyclization ...

Eder, U. Sauer, G. and Wiechert, R. (1971) New Type of Asymmetric Cyclization to Optically Active Steroid CD Partial Structures. Angewandte Chemie International Edition, 10, 496-497.

Researchers determine the detailed mechanism of cyclization catalyzed by the cyclization domain of cyclic β-1,2-glucan synthase from Thermoanaerobacter italicus.

Understanding of the effects of the backbone cyclization on the structure and dynamics of a protein is essential for using protein topology engineering to alter protein stability and function. Here we ...