CRISPRi comes into its own for modeling druggability and validating hits from a KO screen, and CRISPRa supports the understanding of drug-gene interactions. Horizon has developed a dual screening ...

CRISPR interference (CRISPRi) is a novel method for specific gene knockdown. It's CRISPR, without the cut. The Horizon CRISPRi system uses a deactivated Cas9 nuclease (dCas9) fused to our proprietary ...