Chinese companies are involved in one-fifth of pharma’s clinical development programs, but trade wars and regulatory hurdles ...

Advancements in genome editing, particularly CRISPR, are reshaping precision biology, driving innovations in medicine, agriculture, and synthetic biology.

CRISPR-Cas systems have been exploited for targeted genome editing. CRISPR-Cas13 RNA-targeting systems comprise an invaluable set of tools in the fields of basic and applied sciences. Here ...

The application of the type II CRISPR effector protein Cas9 as a sequence-specific nuclease in gene editing has revolutionized this field. Similarly, Cas13 as the effector protein of type VI provides ...

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CRISPR-Cas12 and CRISPR-Cas13 exhibit targeted recognition and cleavage of double-stranded DNA (dsDNA) and RNA, respectively (Pickar-Oliver and Gersbach, 2019). When selectively targeting homologous ...

New CRISPR systems got discovered, like Cas12, CAs12a, but also Cas13, Cas 5, Cas8, Csx10, etc… For now, most of the research efforts for human medicine are concentrated on CAs9 and CAs12. If you are ...

It is the most studied CRISPR gene editing technique, even if others exist like CRISPR-Cas12 or Cas13. The company was founded in 2017 with a focus on developing the technology of “base editing”.

In this study, we developed a novel diagnostic tool targeting the speB gene of GAS, designated GAS-MCDA-CRISPR, for the simple, rapid, and sensitive diagnosis of GAS infections. The detection platform ...

In particular, RNA-targeting CRISPR-Cas13 proteins are promising single-effector systems to regulate target mRNAs without altering genomic DNA, yet the current Cas13 systems are restrained by ...